Essien E M, Okogun J I
Thromb Haemost. 1976 Dec 31;36(3):525-31.
The clot-promoting activity of the aqueous extract of Fagara-zanthoxyloides Lam plant is described for the first time. It significantly shortened the PTT (K) of normal and factor VIII deficient plasma while it manifested no such action on factor IX-deficient plasma. This activity could be demonstrated in the residue of the lyophilized aqueous extract after its successive extraction with ether, chloroform and methanol. It could not be attributed to the purified fractions: Zanthoxylol or its modified form 3, 4-dihydro-2,2-dimethyl-2H-1 benzopyran-6-butyric acid (DBA), hesperidin, Fagaramide or the ether soluble fraction of the aqueous extract.
首次描述了两面针植物水提取物的促凝活性。它显著缩短了正常血浆和因子VIII缺乏血浆的部分凝血活酶时间（K），而对因子IX缺乏血浆则无此作用。在用乙醚、氯仿和甲醇连续萃取冻干水提取物的残渣中可证明这种活性。它不能归因于纯化的组分：花椒醇或其修饰形式3,4-二氢-2,2-二甲基-2H-1-苯并吡喃-6-丁酸（DBA）、橙皮苷、两面针酰胺或水提取物的醚溶性部分。
