火棘提取物对血液凝固的影响

[Effects of pyracantha fortuneana extract on blood coagulation].

作者信息

Mei X, Wan G, Zhou Z, Chang J, Wu H

机构信息

Life School of Science and Technology, Huazhong University of Science and Technology, Wuhan 430074.

出版信息

Zhong Yao Cai. 2001 Dec;24(12):874-6.

PMID:11917844

Abstract

OBJECTIVE

To study the effect of the Pyracantha fortuneana extract and its defferent polar fractions on blood coagulation.

METHODS AND RESULTS

The Pyracantha fortuneana extract could noticeably shorten the coagulation time of glass slide in mice (P < 0.05) after oral administration, and also shorten the recalcification time and prothrombin time in vitro (P < 0.01, P < 0.05), while in three polar fractions of the extract, the effects of the chloroform phase that could shorten the coagulation time of glass slide in mice(P < 0.01) after oral administration, and also shorten the recalcification time and prothrombin time in vitro (P < 0.01) are more noticeable than that of the acetic ether phase (P < 0.01, P < 0.05). The petroleum ether phase has no above-mentioned effect (P > 0.05).

CONCLUSION

The Pyracantha fortuneana extract can reduce the blood coagulation. Both the chloroform phase and the acetic ether phase of the extract have activity of blood coagulation, but the petroleum ether phase does not.

摘要

目的

研究火棘提取物及其不同极性部位对凝血的影响。

方法与结果

火棘提取物灌胃后能显著缩短小鼠玻片法凝血时间（P<0.05），并能缩短体外复钙时间和凝血酶原时间（P<0.01，P<0.05）；提取物的3个极性部位中，氯仿相灌胃后能显著缩短小鼠玻片法凝血时间（P<0.01），并能缩短体外复钙时间和凝血酶原时间（P<0.01），其作用较乙酸乙酯相明显（P<0.01，P<0.05）；石油醚相无上述作用（P>0.05）。