Cucuianu M P, Miloszewski K, Porutiu D, Losowsky M S
Thromb Haemost. 1976 Dec 31;36(3):542-50.
Plasma factor XIII activity measured by a quantitative assay was found to be significantly higher in hypertriglyceridaemic patients (type IV and combined hyperlipoproteinaemia), as compared to normolipaemic controls. No such elevation in plasma factor XIII activity was found in patients with type Ha hyperlipaemia. Plasma pseudocholinesterase was found to parallel the elevated factor XIII activity in hypertriglyceridaemic subjects. In contrast, platelet factor XIII activity was not raised in hyperlipaemic subjects, and plasma factor XIII was found to be normal in a normolipaemic subjects with thrombocythaemia. It was concluded that there is no significant contribution from platelets to plasma factor XIII activity, and that the observed increase in plasma factor XIII in hypertriglyceridaemia results from enhanced hepatic synthesis of the enzyme.
通过定量测定发现，与血脂正常的对照组相比，高甘油三酯血症患者（IV型和混合型高脂蛋白血症）的血浆因子XIII活性显著更高。在IIa型高脂血症患者中未发现血浆因子XIII活性有此类升高。在高甘油三酯血症受试者中，发现血浆假性胆碱酯酶与升高的因子XIII活性平行。相反，高脂血症受试者的血小板因子XIII活性未升高，并且在一名血脂正常但患有血小板增多症的受试者中发现血浆因子XIII正常。得出的结论是，血小板对血浆因子XIII活性没有显著贡献，并且在高甘油三酯血症中观察到的血浆因子XIII增加是由于该酶的肝脏合成增强所致。
