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利用免疫过氧化物酶技术对人组织中因子XIII进行定位。

Localisation of factor XIII in human tissues using an immunoperoxidase technique.

作者信息

Fear J D, Jackson P, Gray C, Miloszewski K J, Losowsky M S

出版信息

J Clin Pathol. 1984 May;37(5):560-3. doi: 10.1136/jcp.37.5.560.

DOI:10.1136/jcp.37.5.560
PMID:6373832
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC498780/
Abstract

An immunoperoxidase technique has been used to localise clotting factor XIII subunits A and S in human tissues. The presence of factor XIII in placenta and megakaryocytes was confirmed. Factor XIII was also found in fibroblasts, a hitherto unreported finding. Factor XIII subunits were not detected in hepatocytes, although factor XIII was found in fibroblasts in portal tracts. These findings suggest that factor XIII is not synthesised in the liver as previously thought.

摘要

已采用免疫过氧化物酶技术在人体组织中定位凝血因子 XIII 的 A 亚基和 S 亚基。证实了胎盘和巨核细胞中存在因子 XIII。在成纤维细胞中也发现了因子 XIII，这是迄今未报道的发现。尽管在门管区的成纤维细胞中发现了因子 XIII，但在肝细胞中未检测到因子 XIII 亚基。这些发现表明，因子 XIII 并非如先前认为的那样在肝脏中合成。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/98c3/498780/329781d51b9e/jclinpath00176-0082-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/98c3/498780/3ad13cf26d6b/jclinpath00176-0081-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/98c3/498780/329781d51b9e/jclinpath00176-0082-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/98c3/498780/3ad13cf26d6b/jclinpath00176-0081-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/98c3/498780/329781d51b9e/jclinpath00176-0082-a.jpg

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1
Localisation of factor XIII in human tissues using an immunoperoxidase technique.利用免疫过氧化物酶技术对人组织中因子XIII进行定位。
J Clin Pathol. 1984 May;37(5):560-3. doi: 10.1136/jcp.37.5.560.
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Immunohistological demonstration of factors XIIIa and XIIIs in reactive and neoplastic fibroblastic and fibro-histiocytic lesions.活化因子XIII和XIII前体在反应性及肿瘤性成纤维细胞和纤维组织细胞性病变中的免疫组织学显示
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Prenatal diagnosis of factor 13 deficiency and its recurrence.产前诊断因子 13 缺乏症及其复发。
BMJ Case Rep. 2020 Dec 22;13(12):e236365. doi: 10.1136/bcr-2020-236365.
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Catridecacog: a breakthrough in the treatment of congenital factor XIII A-subunit deficiency?卡曲凝血酶原复合物：先天性因子ⅩⅢ A亚基缺乏症治疗的突破？

本文引用的文献

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An approach to the metabolism of factor XIII.因子 XIII 的代谢研究方法。
Nihon Ketsueki Gakkai Zasshi. 1981 Dec;44(7):1499-505.
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Plasma factor XIII levels in children with renal disease.
Nephron. 1981;27(1):19-24. doi: 10.1159/000182014.
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Beta-thromboglobulin levels in the nephrotic syndrome.
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J Blood Med. 2014 Jul 9;5:107-13. doi: 10.2147/JBM.S35395. eCollection 2014.
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"Dermal dendritic cells" comprise two distinct populations: CD1+ dendritic cells and CD209+ macrophages.“真皮树突状细胞”包括两个不同的群体：CD1+树突状细胞和CD209+巨噬细胞。
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Inducible expression of MS-1 high-molecular-weight protein by endothelial cells of continuous origin and by dendritic cells/macrophages in vivo and in vitro.连续来源的内皮细胞以及体内和体外的树突状细胞/巨噬细胞对MS-1高分子量蛋白的可诱导表达。
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Characterisation of connective tissue cells containing factor XIII subunit a.含凝血因子 XIII a 亚基的结缔组织细胞的特征描述
J Clin Pathol. 1988 Jan;41(1):49-56. doi: 10.1136/jcp.41.1.49.
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Immunohistochemical detection of factor XIII subunit a in histiocytes of human uterus.人子宫组织细胞中因子 XIII a 亚基的免疫组化检测
Histochemistry. 1989;91(2):169-74. doi: 10.1007/BF00492391.
10
Hemopoietic origin of factor XIII A subunits in platelets, monocytes, and plasma. Evidence from bone marrow transplantation studies.血小板、单核细胞和血浆中因子 XIII A 亚基的造血起源。来自骨髓移植研究的证据。
J Clin Invest. 1989 Sep;84(3):787-92. doi: 10.1172/JCI114237.
[Molecular structure of human fibrin stabilizing factors].
[人纤维蛋白稳定因子的分子结构]
Blut. 1972 Oct;25(4):235-48. doi: 10.1007/BF01632188.
5
Platelet function in hyperlipoproteinemia.高脂蛋白血症中的血小板功能。
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Intravascular coagulation and the liver.
Br J Haematol. 1975 May;30(1):1-7. doi: 10.1111/j.1365-2141.1975.tb00511.x.
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Plasma factor XIII and platelet factor XIII in hyperlipaemia.高脂血症中的血浆因子 XIII 和血小板因子 XIII
Thromb Haemost. 1976 Dec 31;36(3):542-50.
8
Quantitative estimation of coagulation factors in liver disease. The diagnostic and prognostic value of factor XIII, factor V and plasminogen.肝病中凝血因子的定量评估。因子XIII、因子V和纤溶酶原的诊断及预后价值。
Thromb Haemost. 1978 Jun 30;39(3):646-56.