Anwar N, Ahmad K
Bangladesh Med Res Counc Bull. 1976 Jun;2(1):21-6.
The level of y-aminobutyric acid (GABA) was determined in the brain of rats 1 hr. after i.p. injection of chlorpromazine, prochlorperazine, diazepam, trimipramine, methamphetamine and nikethamide. Diazepam increased, and, trimipramine and amphetamine decreased the brain GABA level over wide dose ranges. Low doses of chlorpromazine and prochlorperazine increased but high doses of the drugs reduced the GABA level. Low doses of nikethamide reduced whereas high doses increased the level of GABA. The effects of the drugs have been discussed in relation to the brain GABA level.
在腹腔注射氯丙嗪、丙氯拉嗪、地西泮、曲米帕明、甲基苯丙胺和尼可刹米1小时后，测定大鼠脑中γ-氨基丁酸（GABA）的水平。地西泮在很宽的剂量范围内可使脑GABA水平升高，而曲米帕明和苯丙胺则使其降低。低剂量的氯丙嗪和丙氯拉嗪可使GABA水平升高，但高剂量时则降低。低剂量的尼可刹米可降低GABA水平，而高剂量时则使其升高。已结合脑GABA水平对这些药物的作用进行了讨论。
