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出血后缺铁。临床病程、59铁全身铁丢失及口服铁剂补充

Posthaemorrhagic iron deficiency. Clinical course, 59Fe whole-body iron losses, and oral iron supplementation.

作者信息

Hausmann K, Kuse R, Meinecke K H, Bartels H, Gabbe E E, Heinrich H C

出版信息

Arzneimittelforschung. 1976;26(10):1884-91.

PMID:1037208
Abstract

Clinical and laboratory data characterizing post-haemorrhagic anaemia with still normal iron stores and posthaemorrhagic iron deficiency in the manifest, latent or prelatent stage are presented. Initially, increased 59Fe whole-body iron losses (greater than 0.1-3.6%/day) returned to normal range (less than 0.1%/day) after haemostasis. Subsequently, slow increase of haemoglobin and repletion of iron stores occurred under normal diets. Manifest, latent, and prelatent iron deficiencies were corrected much more rapidly by total doses of 12.0, 10.5 and 8.0 g iron (Fe2+ sulfate), respectively, when 2 X 50 mg/day were given in quick-release capsules apart from meals.

摘要

本文介绍了具有正常铁储备的出血后贫血以及明显、潜在或潜伏阶段的出血后缺铁的临床和实验室数据特征。最初,59Fe全身铁流失增加(大于0.1 - 3.6%/天),止血后恢复到正常范围(小于0.1%/天)。随后,在正常饮食情况下,血红蛋白缓慢增加且铁储备得到补充。当除餐外每天分两次服用速释胶囊,每次50毫克时,分别给予12.0克、10.5克和8.0克铁(硫酸亚铁)的总剂量可更快速地纠正明显、潜在和潜伏性铁缺乏。

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Arzneimittelforschung. 1976;26(10):1884-91.
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