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口服铁剂治疗:肠道吸收及进餐的影响(作者译)

[Oral iron treatment: intestinal absorption and the influence of a meal (author's transl)].

作者信息

Werner E, Kaltwasser J P, Ihm P

出版信息

Dtsch Med Wochenschr. 1977 Jul 22;102(29):1061-4. doi: 10.1055/s-0028-1105464.

DOI:10.1055/s-0028-1105464
PMID:408116
Abstract

Intestinal iron absorption after a single dose of a special galenic preparation (50 and 100 mg iron as ferrous glycocoll sulphate in micropellets) was investigated in 105 persons with normal iron stores (42), latent (40) or manifest iron deficiency (23). Absorption rate rate on fasting as well as after breakfast was measured in 21 persons. Intestinal absorption increased in persons with iron deficiency, but maximal absorption after a single dose of 100 mg did not exceed 25%. This absorption rate was already reached in persons with latent iron deficiency. There was no significant reduction of absorption when the preparation was given at the end of breakfast.

摘要

对105名铁储备正常(42人)、潜在缺铁(40人)或明显缺铁(23人)的受试者,研究了单次服用一种特殊药剂(50毫克和100毫克硫酸甘氨酸亚铁微丸形式的铁)后的肠道铁吸收情况。对21名受试者测量了空腹及早餐后铁的吸收率。缺铁人群的肠道铁吸收增加,但单次服用100毫克后的最大吸收率未超过25%。潜在缺铁人群已达到这一吸收率。在早餐结束时服用该药剂,吸收率没有显著降低。

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