Kaltwasser J P, Werner E, Becker H
Dtsch Med Wochenschr. 1977 Aug 12;102(32):1150-5. doi: 10.1055/s-0028-1105476.
Ferrritin can be measured in blood serum radioimmunometrically. Serum ferritin is directly correlated to body iron stores. In comparison to other parameters of storage iron (bone marrow iron, intestinal iron absorption) this quantitative diagnostic parameter is easily available. Thus it can be used to judge body iron status. In 20 patients with chronic haemorrhagic and 7 patients with posthaemorrhagic iron deficiency anaemia as well as nine blood donors with latent iron deficiency serum ferritin was used to control oral iron therapy. The continuous determination of serum ferritin during therapy gives a quantitative value of the relevant level of body iron stores. This value shows whether therapy was effective and when iron stores are replenished. The results demonstrate that oral iron therapy should be continued for at least 3 months from the time of normalisation of haemoglobin to obtain a sufficient restoration of iron depots.
血清铁蛋白可通过放射免疫测定法在血清中进行检测。血清铁蛋白与体内铁储存直接相关。与储存铁的其他参数(骨髓铁、肠道铁吸收)相比,这个定量诊断参数易于获取。因此它可用于判断身体的铁状态。在20例慢性出血性患者、7例出血后缺铁性贫血患者以及9例潜在缺铁的献血者中,血清铁蛋白被用于监测口服铁剂治疗。治疗期间持续测定血清铁蛋白可得出体内铁储存相关水平的定量值。该值显示治疗是否有效以及铁储存何时得到补充。结果表明,口服铁剂治疗应从血红蛋白正常化之时起持续至少3个月,以充分恢复铁储备。