Nyrén M, Hagströmer L, Emtestam L
Department of Dermatology and Venereology, Karolinska Institute, Huddinge University Hospital, Sweden.
Ann N Y Acad Sci. 1999 Apr 20;873:214-20. doi: 10.1111/j.1749-6632.1999.tb09469.x.
Pathophysiological events in biological tissue are characterized by a shift in electrical impedance spectra of the tissue under study. In this paper, techniques based on electrical impedance are reviewed with emphasis on their possible role in evaluating the skin reactivity of an individual, including results from impedance measurement studies on patients with allergic contact reactions, wheals, tuberculin tests, and irritant contact reactions and on an appropriate number of controls. The results show that, compared to relevant controls, at different types of experimental cutaneous reactions, both of allergic and irritant type, statistically significant changes of the impedance parameters have been detected. Each reaction type had a specific impedance index pattern. Data up to now indicate that the improved impedance technique offers not only a noninvasive alternative for characterization and perhaps differentiation between the skin responses induced by either an allergen or an irritant, but also a capability to distinguish responses induced by chemically different irritants.
生物组织中的病理生理事件的特征是所研究组织的电阻抗谱发生变化。本文综述了基于电阻抗的技术，重点介绍了它们在评估个体皮肤反应性方面的潜在作用，包括对过敏性接触反应、风团、结核菌素试验、刺激性接触反应患者以及适当数量对照进行阻抗测量研究的结果。结果表明，与相关对照相比，在过敏性和刺激性这两种不同类型的实验性皮肤反应中，均检测到阻抗参数有统计学意义的变化。每种反应类型都有特定的阻抗指数模式。目前的数据表明，改进后的阻抗技术不仅为表征以及区分由过敏原或刺激物引起的皮肤反应提供了一种非侵入性替代方法，还具备区分由化学性质不同的刺激物引起的反应的能力。
