通过电阻抗评估皮肤过敏接触反应——一项初步研究。

Allergic contact reactions in the skin assessed by electrical impedance - a pilot study.

作者信息

Nicander I, Ollmar S, Rozell B L, Emtestam L

机构信息

1Department of Dermatology, Huddinge University Hospital2Center for Oral Biology, Karolinska Institute, NOVUM3Department of Pathology, Huddinge University Hospital, Huddinge, Sweden.

出版信息

Skin Res Technol. 1997 May;3(2):121-5. doi: 10.1111/j.1600-0846.1997.tb00173.x.

DOI:10.1111/j.1600-0846.1997.tb00173.x

PMID:27333373

Abstract

BACKGROUND/AIMS: In our previous studies of the electrical impedance of the skin, we formulated a set of physical indices that could be used to distinguish between the cutaneous effects produced by different chemical irritants. We now describe an investigation of allergic contact reactions, using the same set of impedance indices for characterization.

METHODS

Skin reactions were induced in the forearm of eight female patients who were allergic to nickel by exposure to nickel sulphate in petrolatum at various concentrations. The responses were evaluated by measurements of electrical impedance and transepidermal water loss, as well as by visual scoring and biopsy. Normal skin was used for controls.

RESULTS

Different degrees of allergic contact reactions were produced, and the changes in value of the impedance indices were found to follow a particular pattern. This pattern diverged markedly from that obtained in controls, and the differences were statistically significant.

CONCLUSIONS

Our results suggest that, by the application of a technique based on electrical impedance, it will be possible to characterize allergic skin reactions.

摘要

背景/目的：在我们之前对皮肤电阻抗的研究中，我们制定了一套物理指标，可用于区分不同化学刺激物产生的皮肤效应。我们现在描述一项关于过敏性接触反应的研究，使用同一套阻抗指标进行特征描述。