Nicander I, Ollmar S, Rozell B L, Emtestam L
1Department of Dermatology, Huddinge University Hospital2Center for Oral Biology, Karolinska Institute, NOVUM3Department of Pathology, Huddinge University Hospital, Huddinge, Sweden.
Skin Res Technol. 1997 May;3(2):121-5. doi: 10.1111/j.1600-0846.1997.tb00173.x.
BACKGROUND/AIMS: In our previous studies of the electrical impedance of the skin, we formulated a set of physical indices that could be used to distinguish between the cutaneous effects produced by different chemical irritants. We now describe an investigation of allergic contact reactions, using the same set of impedance indices for characterization.
Skin reactions were induced in the forearm of eight female patients who were allergic to nickel by exposure to nickel sulphate in petrolatum at various concentrations. The responses were evaluated by measurements of electrical impedance and transepidermal water loss, as well as by visual scoring and biopsy. Normal skin was used for controls.
Different degrees of allergic contact reactions were produced, and the changes in value of the impedance indices were found to follow a particular pattern. This pattern diverged markedly from that obtained in controls, and the differences were statistically significant.
Our results suggest that, by the application of a technique based on electrical impedance, it will be possible to characterize allergic skin reactions.
背景/目的：在我们之前对皮肤电阻抗的研究中，我们制定了一套物理指标，可用于区分不同化学刺激物产生的皮肤效应。我们现在描述一项关于过敏性接触反应的研究，使用同一套阻抗指标进行特征描述。
对8名对镍过敏的女性患者的前臂皮肤进行反应诱导，通过接触不同浓度凡士林硫酸镍。通过测量电阻抗和经表皮水分流失，以及视觉评分和活检来评估反应。以正常皮肤作为对照。
产生了不同程度的过敏性接触反应，发现阻抗指标值的变化遵循特定模式。该模式与对照组明显不同，差异具有统计学意义。
我们的结果表明，通过应用基于电阻抗的技术，将有可能对过敏性皮肤反应进行特征描述。
