果蝇中凋亡细胞吞噬作用对croquemort的需求。
Requirement for croquemort in phagocytosis of apoptotic cells in Drosophila.
作者信息
Franc N C, Heitzler P, Ezekowitz R A, White K
机构信息
Cutaneous Biology Research Center, Laboratory of Developmental Immunology, and Department of Pediatrics, Massachusetts General Hospital, Harvard Medical School. Charlestown, MA 02129, USA.
出版信息
Science. 1999 Jun 18;284(5422):1991-4. doi: 10.1126/science.284.5422.1991.
Macrophages in the Drosophila embryo are responsible for the phagocytosis of apoptotic cells and are competent to engulf bacteria. Croquemort (CRQ) is a CD36-related receptor expressed exclusively on these macrophages. Genetic evidence showed that crq was essential for efficient phagocytosis of apoptotic corpses but was not required for the engulfment of bacteria. The expression of CRQ was regulated by the amount of apoptosis. These data define distinct pathways for the phagocytosis of corpses and bacteria in Drosophila.
果蝇胚胎中的巨噬细胞负责凋亡细胞的吞噬作用，并且能够吞噬细菌。Croquemort（CRQ）是一种仅在这些巨噬细胞上表达的与CD36相关的受体。遗传学证据表明，crq对于凋亡尸体的有效吞噬至关重要，但对于细菌的吞噬并非必需。CRQ的表达受凋亡量的调节。这些数据定义了果蝇中尸体和细菌吞噬的不同途径。
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