Platt N, da Silva R P, Gordon S
Sir William Dunn School of Pathology, Oxford, UK. nick.platt/path.ox.ac.uk
Trends Cell Biol. 1998 Sep;8(9):365-72. doi: 10.1016/s0962-8924(98)01329-4.
Although apoptotic cell death is widespread, dying cells are rarely seen in situ because of their rapid clearance by neighbouring phagocytes. Phagocytic recognition of apoptotic cells is less well understood than the death programme itself, but an increasing number of recent studies are highlighting its importance. This review discusses the nature of the receptors that have been implicated in apoptotic cell phagocytosis, the mechanisms of uptake and the immunological consequences of apoptotic cell ingestion.
虽然凋亡性细胞死亡很普遍，但由于临近吞噬细胞会迅速清除死亡细胞，因此原位很少能看到垂死细胞。相较于死亡程序本身，对凋亡细胞的吞噬识别了解较少，但最近越来越多的研究凸显了其重要性。本综述讨论了与凋亡细胞吞噬作用有关的受体性质、摄取机制以及凋亡细胞吞噬的免疫学后果。
