Wu J, Yin K, Yang Y
First Affiliated Hospital, Nanjing Medical University.
Zhonghua Nei Ke Za Zhi. 1997 Apr;36(4):238-41.
To understand the roles of autoantibodies to beta 2 adrenergic receptors in the pathogenesis of asthma, we investigated the positive chronotropic action of beta 2-selective adrenergic agonist, clenbuterol, on cultured neonatal rat cardiomyocytes. Thereafter, we detected the autoantibodies to beta 2-adrenergic receptors in the sera from patients with asthma as it could inhibit the positive chronotropic action of clenbuterol. In the sera of all patients with asthma (16 cases) there were autoantibodies to beta 2-adrenergic receptors, but not in the normal controls (20 cases). Further study showed that the inhibitory autoantibodies were IgG type. This experiment suggests that the autoantibodies to beta 2-adrenergic receptors may play an important role in the pathogenesis of asthma.
为了解β2肾上腺素能受体自身抗体在哮喘发病机制中的作用，我们研究了β2选择性肾上腺素能激动剂克伦特罗对培养的新生大鼠心肌细胞的正性变时作用。此后，我们检测了哮喘患者血清中β2肾上腺素能受体自身抗体，因为其可抑制克伦特罗的正性变时作用。在所有哮喘患者（16例）血清中均存在β2肾上腺素能受体自身抗体，而正常对照者（20例）血清中则无。进一步研究表明，抑制性自身抗体为IgG型。本实验提示，β2肾上腺素能受体自身抗体可能在哮喘发病机制中起重要作用。
