睡眠-觉醒期间大鼠海马体中细胞外5-羟色胺的体内微透析测量
In vivo microdialysis measures of extracellular serotonin in the rat hippocampus during sleep-wakefulness.
作者信息
Park S P, Lopez-Rodriguez F, Wilson C L, Maidment N, Matsumoto Y, Engel J
机构信息
Department of Neurology, Kyungpook National University School of Medicine, Taegu 700-412, South Korea.
出版信息
Brain Res. 1999 Jul 3;833(2):291-6. doi: 10.1016/s0006-8993(99)01511-5.
We investigated extracellular 5-hydroxytryptamine (5-HT) levels in rat hippocampus during different stages of the sleep-waking cycle using in vivo microdialysis. The extracellular 5-HT level was highest in active waking (AW) and, when compared to AW, 5-HT level was progressively lower in quiet waking (QW; 78%), quiet sleep (QS; 50%) and REM (which we termed active sleep (AS); 40%). Functional implications of AS related-decreased 5-HT in the hippocampus are discussed.
我们使用体内微透析技术研究了大鼠睡眠-觉醒周期不同阶段海马体中的细胞外5-羟色胺（5-HT）水平。细胞外5-HT水平在主动觉醒（AW）时最高，与AW相比，在安静觉醒（QW；降低78%）、安静睡眠（QS；降低50%）和快速眼动睡眠（我们称之为主动睡眠（AS）；降低40%）时5-HT水平逐渐降低。文中讨论了海马体中与主动睡眠相关的5-HT减少的功能意义。
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