吲哚美辛对大鼠和兔关节损伤的影响。
Effects of indomethacin on joint damage in rat and rabbit.
作者信息
Wang B, Yao Y Y, Chen M Z
机构信息
Institute of Clinical Pharmacology, Anhui Medical University, Hefei, China.
出版信息
Zhongguo Yao Li Xue Bao. 1998 Jan;19(1):70-3.
AIM
To study the effects of indometacin (Ind) on joint damages.
METHODS
The volume of noninjected hind paw and interleukin-1 (IL-1) production from peritoneal macrophages and articular synoviocytes induced by lipopolysaccharides were assayed in adjuvant arthritis (AA) rats. Measurements of synovial fibroblast proliferative response and proteoglycan synthesis of cartilage from rabbits were used.
RESULTS
The secondary inflammatory reactions in AA rats on d 18, 21, and 24 were suppressed by i.g. Ind 2 mg.kg-1.d-1 for 9 d. Ind promoted IL-1 production from both macrophages and synoviocytes in AA rats. Ind 10 mumol.L-1 enhanced the proliferation of rabbit synovial fibroblasts and suppressed the proteoglycan synthesis of articular cartilage in response to IL-1 in vitro.
CONCLUSION
Ind is unfavorable to the repair of joint destruction.
目的
研究吲哚美辛（Ind）对关节损伤的影响。
方法
在佐剂性关节炎（AA）大鼠中检测未注射后爪的体积以及脂多糖诱导的腹膜巨噬细胞和关节滑膜细胞产生白细胞介素-1（IL-1）的情况。采用兔滑膜成纤维细胞增殖反应及软骨蛋白聚糖合成的检测方法。
结果
第18、21和24天，AA大鼠的继发性炎症反应被每天2mg·kg-1的吲哚美辛灌胃9天所抑制。吲哚美辛促进AA大鼠巨噬细胞和滑膜细胞产生IL-1。在体外，10μmol·L-1的吲哚美辛增强兔滑膜成纤维细胞的增殖，并抑制关节软骨对IL-1刺激的蛋白聚糖合成。
结论
吲哚美辛不利于关节破坏的修复。
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