Wang B, Chen M Z
Institute of Clinical Pharmacology, Anhui Medical University, Hefei, China.
Int J Tissue React. 1998;20(3):91-4.
In this study the effects of indomethacin on secondary inflammatory reaction and secretory function of synoviocytes were analyzed. The results show that secondary inflammatory reaction in adjuvant arthritis rats on days 16, 20 and 22 was suppressed significantly by intragastric administration of indomethacin in a dose of 2 mg/kg-1/d-1 for 10 days. Synoviocytes from adjuvant arthritis rats released a higher level of interleukin (IL)-1 and tumor necrosis factor (TNF) than that from the normal, control group. The synoviocyte culture supernatants of adjuvant arthritis rats were able to enhance the proliferation of synovial fibroblasts from normal rats in vitro. The synovial fibroblast proliferation mediated by the synoviocyte culture supernatants of adjuvant arthritis rats treated with indomethacin was promoted further because of the inhibition of prostaglandin (PG)E2 synthesis and the enhancement of IL-1 and TNF production in the synoviocytes from these animals. These results suggest that indomethacin is an effective antiinflammatory agent, but it is disadvantageous to the repair of joint destruction.
本研究分析了吲哚美辛对滑膜细胞继发性炎症反应及分泌功能的影响。结果显示，对佐剂性关节炎大鼠连续10天灌胃给予剂量为2 mg/kg-1/d-1的吲哚美辛，可显著抑制其在第16、20和22天的继发性炎症反应。佐剂性关节炎大鼠的滑膜细胞释放的白细胞介素（IL）-1和肿瘤坏死因子（TNF）水平高于正常对照组。佐剂性关节炎大鼠的滑膜细胞培养上清液能够在体外增强正常大鼠滑膜成纤维细胞的增殖。由于抑制了前列腺素（PG）E2合成并增强了这些动物滑膜细胞中IL-1和TNF的产生，用吲哚美辛处理的佐剂性关节炎大鼠的滑膜细胞培养上清液介导的滑膜成纤维细胞增殖进一步受到促进。这些结果表明，吲哚美辛是一种有效的抗炎药，但对关节破坏的修复不利。
