Williams T A, Riddle M, Morgan S L, Brewer W E
Department of Chemistry & Biochemistry, University of South Carolina, Columbia 29208, USA.
J Chromatogr Sci. 1999 Jun;37(6):210-4. doi: 10.1093/chromsci/37.6.210.
High-speed gas chromatographic (GC) screening for drugs of forensic relevance is performed using a commercial Flash GC instrument in which the chromatographic column is resistively heated at rates of up to 30 degrees C/s. Temperature programming conditions are varied in an experiment designed to evaluate trade-offs between resolution and analysis time for a mixture of 19 drugs of abuse. All 19 components can be separated with excellent resolution in 90 s. Specific analytes can be analyzed even faster; for example, amphetamine analysis is completed in less than 20 s. Case studies of confiscated street drugs containing amphetamine, cocaine, and heroin are analyzed to evaluate the retention time repeatability. Ten replicate injections over a 2-day period for 3 different drug samples achieved retention time relative standard deviations in the range of 0.48 to 0.81%.
使用商用快速气相色谱仪对法医相关药物进行高速气相色谱（GC）筛查，该仪器中的色谱柱以高达30℃/秒的速率进行电阻加热。在一项实验中改变程序升温条件，以评估19种滥用药物混合物在分离度和分析时间之间的权衡。所有19种成分均可在90秒内以出色的分离度分离。特定分析物的分析速度甚至更快；例如，苯丙胺分析可在不到20秒内完成。对含有苯丙胺、可卡因和海洛因的没收街头毒品进行案例研究，以评估保留时间的重复性。在2天内对3种不同药物样品进行10次重复进样，保留时间的相对标准偏差在0.48%至0.81%范围内。
