Grivell L A, Artal-Sanz M, Hakkaart G, de Jong L, Nijtmans L G, van Oosterum K, Siep M, van der Spek H
Section for Molecular Biology, Institute of Molecular Cell Biology, University of Amsterdam, The Netherlands.
FEBS Lett. 1999 Jun 4;452(1-2):57-60. doi: 10.1016/s0014-5793(99)00532-3.
The yeast Saccharomyces cerevisiae is likely to be the first organism for which a complete inventory of mitochondrial proteins and their functions can be drawn up. A survey of the 340 or so proteins currently known to be localised in yeast mitochondria reveals the considerable investment required to maintain the organelle's own genetic system, which itself contributes seven key components of the electron transport chain. Translation and respiratory complex assembly are particularly expensive processes, together requiring around 150 of the proteins so far known. Recent developments in both areas are reviewed and approaches to the identification of novel mitochondrial proteins are discussed.
酿酒酵母很可能是首个能够列出线粒体蛋白质及其功能完整清单的生物。对目前已知定位于酵母线粒体中的约340种蛋白质进行的一项调查显示，维持该细胞器自身遗传系统需要大量投入，该遗传系统本身贡献了电子传递链的七个关键组分。翻译和呼吸复合体组装是特别耗费资源的过程，目前已知的约150种蛋白质共同参与其中。本文综述了这两个领域的最新进展，并讨论了鉴定新型线粒体蛋白质的方法。
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