Donohue-Rolfe A, Kondova I, Mukherjee J, Chios K, Hutto D, Tzipori S
Division of Infectious Diseases, Tufts University School of Veterinary Medicine, North Grafton, Massachusetts 01536, USA.
Infect Immun. 1999 Jul;67(7):3645-8. doi: 10.1128/IAI.67.7.3645-3648.1999.
Hemolytic-uremic syndrome (HUS) is a serious disease in children, attributable in the majority of cases to infection with Shiga toxin (Stx)-producing Escherichia coli. Using gnotobiotic piglets orally infected with E. coli O157:H7, which develop Stx-related cerebellar lesions and fatal neurological symptoms, we show that administration of Stx2-specific antiserum well after challenge protected, in a dose-response fashion, against these symptoms for at least 24 h after bacterial challenge. Twenty-six of 30 piglets given Stx2 antiserum survived the challenge, compared to only 4 of 16 animals given control serum or saline. Given our observations in piglets, Stx antibody of human origin may likewise prevent HUS in children.
溶血尿毒综合征（HUS）是一种发生于儿童的严重疾病，在大多数情况下是由产志贺毒素（Stx）的大肠杆菌感染所致。我们利用经口服感染大肠杆菌O157:H7的无菌仔猪（这些仔猪会出现与Stx相关的小脑病变和致命的神经症状）进行研究，结果表明在感染后较长时间给予Stx2特异性抗血清，能以剂量依赖的方式在细菌感染后至少24小时内保护仔猪免受这些症状的影响。给予Stx2抗血清的30头仔猪中有26头在感染后存活下来，而给予对照血清或生理盐水的16头动物中只有4头存活。基于我们在仔猪身上的观察结果，人源Stx抗体同样可能预防儿童HUS。
