肺炎链球菌荚膜多糖含量的菌株内变异对其遗传转化的影响：对荚膜菌株毒力研究的启示
Effect of intrastrain variation in the amount of capsular polysaccharide on genetic transformation of Streptococcus pneumoniae: implications for virulence studies of encapsulated strains.
作者信息
Weiser J N, Kapoor M
机构信息
Departments of Pediatrics and Microbiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA.
出版信息
Infect Immun. 1999 Jul;67(7):3690-2. doi: 10.1128/IAI.67.7.3690-3692.1999.
Abstract
The degrees of competence of opaque and transparent colony variants of Streptococcus pneumoniae were compared. The transparent variants were transformed at 9- to 670-fold-higher rates than the opaque variants, independent of the DNA incorporated, due to decreased expression of capsular polysaccharide. Genetic transformation, therefore, tends to select for a less-encapsulated subpopulation.
摘要
比较了肺炎链球菌不透明和透明菌落变体的感受态程度。由于荚膜多糖表达降低，透明变体的转化速率比不透明变体高9至670倍，且与掺入的DNA无关。因此，基因转化倾向于选择包膜较少的亚群。
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