Willadsen P, Jongejan F
CSIRO Tropical Agriculture, 120 Meiers Road, Indooroopilly, Queensland 4068, Australia.
Parasitol Today. 1999 Jul;15(7):258-62. doi: 10.1016/s0169-4758(99)01472-6.
The first experimental vaccination against ticks was carried out 60 years ago. Since then, progress has been slow, although the recent commercial release of a recombinant vaccine against Boophilus microplus is significant. The nature of naturally acquired protective immunity against ticks is poorly understood, particularly in the important, domesticated ruminant hosts. Characterization of the antigens of naturally acquired immunity remains limited, although more has been achieved with 'concealed' antigens. Crucial questions remain about the true impact of tick-induced immunosuppression and the effect of immunity on the transmission of tick-borne diseases, despite some fascinating and important recent results, as discussed here by Peter Willadsen and Frans Jongejan.
60年前首次进行了针对蜱虫的实验性疫苗接种。从那时起，进展一直缓慢，尽管最近一种针对微小牛蜱的重组疫苗实现了商业化发布，这意义重大。人们对蜱虫自然获得性保护性免疫的本质了解甚少，尤其是在重要的家养反刍动物宿主中。自然获得性免疫抗原的特征描述仍然有限，尽管在“隐蔽”抗原方面已经取得了更多成果。尽管最近有一些引人入胜且重要的研究结果，但关于蜱虫诱导的免疫抑制的真正影响以及免疫对蜱传疾病传播的影响等关键问题仍然存在，彼得·维拉森和弗兰斯·容格扬在此进行了讨论。
