Gyürüs E, Green A, Patterson C, Soltész G
Pécsi Orvostudományi Egyetem, Gyermekklinika.
Orv Hetil. 1999 May 16;140(20):1107-11.
The incidence of Type 1 diabetes in 2417 children aged 0-14 years was studied between 1978 and 1997. Statistical analysis of the data in the twenty-year period showed a steady increase in incidence of Type 1 diabetes with an average rate of 4.8% (95% CI 4.0-5.5) per annum. The incidence rate was lowest in children aged 0 to 4 years and the highest in the age group 10 to 14 years. This increase in incidence was similar for all age groups, but it was most pronounced in the 10 to 14 year-old age group. One hundred and twenty one of the 1239 families (9.7%), one of parents was also reported to have Type 1 diabetes and in 3 (0.2%) families both parents had Type 1 diabetes. Twenty two (2.3%) of the diabetic families had a sibling with Type 1 diabetes. The nearly three-fold increase in incidence during the last two decades (3.8 per 100,000 per year in 1978; 10.7 per 100,000 per year) was probably due to environmental factors, while the high degree of familial clustering emphasises the role of genetic factors in the etiology of Type 1 diabetes.
1978年至1997年期间，对2417名0至14岁儿童的1型糖尿病发病率进行了研究。对这二十年的数据进行统计分析表明，1型糖尿病发病率呈稳步上升趋势，平均年增长率为4.8%（95%置信区间4.0 - 5.5）。发病率在0至4岁儿童中最低，在10至14岁年龄组中最高。各年龄组的发病率上升情况相似，但在10至14岁年龄组中最为明显。在1239个家庭中，有121个（9.7%）家庭报告父母一方患有1型糖尿病，3个（0.2%）家庭父母双方均患有1型糖尿病。22个（2.3%）糖尿病家庭有一个患1型糖尿病的兄弟姐妹。过去二十年发病率几乎增加了两倍（1978年为每年每10万人中有3.8例；现在为每年每10万人中有10.7例），这可能是环境因素所致，而高度的家族聚集性则凸显了遗传因素在1型糖尿病病因中的作用。
