Gribanov G A, Kostiuk N V, Abramov Iu V, Bykov V A, Rebrov L B, Volodina T V, Pertsov S S
Tver State University.
Vopr Med Khim. 1999 Mar-Apr;45(2):131-5.
The influence of short-form water immersion stress of rats on lipids in the skin, the cerebellum and the medulla oblongata was studied. The level of total lipids and absolute and relative contents of the main lipid fractions (phospholipids, nonesterified cholesterol, free fatty acids, triglycerides, and cholesterol esters) were measured. Stress induced delayed changes of the lipid component of the skin. The first significant changes of lipid fractions were only observed 20 h later after the stress procedure. These changes were retained (being at nearly constant levels) till the end of the second day. The decrease in contents of total lipids and esterified cholesterol was revealed in the cerebellum of stressed rats (in comparison to these levels in control rats). These results suggest the involvement of cholesterol metabolic system in the stress reaction. The content of total lipids decreased also in the medulla oblongata. However, levels of the main lipid fractions changed differently. The content of diglycerides increased and the content of cholesterol decreased. The data obtained suggest that degradation of triglycerides is the principle pathway of metabolic conversions of lipids. Free fatty acids formed during these processes are probably involved in the synthesis of phospholipids and cholesterol esters. The data indicate absolutely different mechanisms of interrelations between individual lipid fractions in the brain regions studied. Various roles of the brain structures in the stress response of the body may account for the differences revealed.
研究了大鼠短时间水浸应激对皮肤、小脑和延髓脂质的影响。测定了总脂质水平以及主要脂质组分（磷脂、非酯化胆固醇、游离脂肪酸、甘油三酯和胆固醇酯）的绝对含量和相对含量。应激导致皮肤脂质成分出现延迟变化。脂质组分的首次显著变化直到应激处理后20小时才观察到。这些变化一直持续（保持在几乎恒定的水平）到第二天结束。应激大鼠的小脑显示总脂质和酯化胆固醇含量降低（与对照大鼠的这些水平相比）。这些结果表明胆固醇代谢系统参与了应激反应。延髓中的总脂质含量也降低。然而，主要脂质组分的水平变化不同。甘油二酯含量增加而胆固醇含量降低。获得的数据表明甘油三酯的降解是脂质代谢转化的主要途径。这些过程中形成的游离脂肪酸可能参与磷脂和胆固醇酯的合成。数据表明在所研究的脑区中各个脂质组分之间的相互关系机制完全不同。所揭示的差异可能是由于脑结构在身体应激反应中的各种作用所致。
