Haider M, Kanz G, Koller M, Schmid H
Wien Klin Wochenschr. 1977 Jan 7;89(1):18-23.
Rats were subjected to two kinds of stress and consequent changes in blood protein and lipids were investigated. Furthermore, an attempt was made to ascertain whether or not increases or decreases in these blood parameters were reproducible by conditioning. In the first experiment animals were subjected to stress in a modified running wheel (Noble Collip drum). A series of 10 conditional stimuli (light-sound combined) was delivered together with the stress-producing stimulus. After the first exposure to stress a relative alpha1-globulin increase was observed. After 10 stress exposures the hitherto neutral stimulus alone produced a conditioned increase in the alpha1-globulin fraction. The gamma-globulin values were decreased after the first exposure to stress, but increased after 10 stress exposures. This increase could also be conditioned. In the second experiment "white noise" stress was used (110 dB). The conditional stimulus was light. After short exposure to the stress-inducing stimulus, the gamma-globulins showed a slight drop and remained thus during the whole experiment. The analysis of blood lipids showed increased stress values for alpha-lipoprotiens and reduced values for beta-fractions. Cholesterol and triglycerides reacted like the beta-lipoproteins. The total blood lipid content was, however, increased. The conditioned increase in alpha-lipoproteins and total lipids was statisticallysignigicant. It is noteworthy that the conditioned alpha-lipoprotein levels shoeed significant differences between experimental and control groups. The conditioned stress increased the levels of cholesterol and triglycerides, whereas under real stress conditions decreases were found. Research on "conditioned stress" could beof improtance in regard to clinical aspects of coronary heart disease.
将大鼠置于两种应激状态下，并研究其血液蛋白质和脂质随之发生的变化。此外，还试图确定这些血液参数的升高或降低是否可通过条件作用重现。在第一个实验中，将动物置于改良的跑步轮（诺布尔·科利普鼓）中施加应激。一系列10种条件刺激（光与声结合）与产生应激的刺激一起给予。首次暴露于应激后，观察到相对α1球蛋白增加。经过10次应激暴露后，单独的先前中性刺激会使α1球蛋白部分产生条件性增加。首次暴露于应激后γ球蛋白值下降，但在10次应激暴露后升高。这种升高也可以形成条件反射。在第二个实验中，使用“白噪声”应激（110分贝）。条件刺激是光。短时间暴露于应激诱导刺激后，γ球蛋白略有下降，并在整个实验过程中保持如此。血脂分析显示α脂蛋白的应激值升高，β组分的值降低。胆固醇和甘油三酯的反应与β脂蛋白相似。然而，全血脂含量增加。α脂蛋白和总脂质的条件性增加具有统计学意义。值得注意的是，条件性α脂蛋白水平在实验组和对照组之间显示出显著差异。条件性应激增加了胆固醇和甘油三酯的水平，而在实际应激条件下则发现降低。关于“条件性应激”的研究在冠心病的临床方面可能具有重要意义。
