细胞因子/趋化因子在结核病免疫中的级联反应
Cytokine/chemokine cascades in immunity to tuberculosis.
作者信息
Orme I M, Cooper A M
机构信息
Mycobacteria Research Laboratories, Dept of Microbiology, Colorado State University, Fort Collins, CO 80523, USA.
出版信息
Immunol Today. 1999 Jul;20(7):307-12. doi: 10.1016/s0167-5699(98)01438-8.
The relationship between acquired specific resistance and delayed-type hypersensitivity (DTH) in immunity to tuberculosis has long been a topic of debate. Here, Ian Orme and Andrea Cooper propose that the events are separate mechanisms; protection is cytokine driven and initially controls the infection, whereas DTH is primarily chemokine driven and functions to wall off the infection and prevent further dissemination.
在结核病免疫中，获得性特异性抗性与迟发型超敏反应（DTH）之间的关系长期以来一直是一个争论的话题。在此，伊恩·奥姆和安德里亚·库珀提出，这两种情况是不同的机制；保护性反应由细胞因子驱动，最初控制感染，而迟发型超敏反应主要由趋化因子驱动，其作用是隔离感染并防止进一步扩散。
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