D'Incà R, Varnier M, Mestriner C, Martines D, D'Odorico A, Sturniolo G C
Department of Surgical and Gastroenterological Sciences, University of Padova, Italy.
Ital J Gastroenterol Hepatol. 1999 Apr;31(3):205-10.
Physical exercise may exacerbate the disturbed homeostasis of Crohn's disease patients.
To examine the effect of moderate physical exercise on gastrointestinal function in a group of Crohn's disease patients in remission.
The effect of one-hour's exercise at a maximum of 60% oxygen consumption was evaluated in six males with ileal Crohn's disease in remission on orocaecal transit time (breath test to lactulose), intestinal permeability (6-hours' urinary excretion of a sugar mixture of lactulose/mannitol), polymorphonuclear leucocytes function (peripheral blood chemiluminescence), lipoperoxidation (plasma malondialdehyde) and antioxidant trace elements (urinary and plasma zinc and copper concentrations). Six healthy age-matched subjects served as controls.
Exercise did not elicit subjective symptoms or changes in intestinal permeability and lipoperoxidation. Orocaecal transit time increased after exercise in Crohn's disease patients (72 min +/- 30 vs 100 min +/- 34) with no significant difference from controls (77 min +/- 20 vs 83 min +/- 23). Neutrophils, primed pre-exercise in Crohn's disease patients showed an increased post-exercise chemiluminescence similar to controls. Zinc urinary output significantly increased after exercise in Crohn's disease patients and remained unchanged in control subjects.
Moderate aerobic exercise has no significant effect on the gastrointestinal parameters examined. However, basal neutrophil activation and exercise in Crohn's disease patients may trigger an excessive production of oxygen metabolites. Moreover, exercise may contribute to an increased risk of zinc deficiency.
体育锻炼可能会加剧克罗恩病患者体内紊乱的内环境稳态。
研究适度体育锻炼对一组处于缓解期的克罗恩病患者胃肠功能的影响。
对6名处于缓解期的回肠克罗恩病男性患者进行了为期1小时、最大耗氧量为60%的运动，评估其对口盲肠转运时间（乳果糖呼气试验）、肠道通透性（乳果糖/甘露醇混合糖6小时尿排泄量）、多形核白细胞功能（外周血化学发光）、脂质过氧化（血浆丙二醛）以及抗氧化微量元素（尿和血浆锌及铜浓度）的影响。选取6名年龄匹配的健康受试者作为对照。
运动未引发主观症状，也未导致肠道通透性和脂质过氧化发生变化。克罗恩病患者运动后口盲肠转运时间延长（72分钟±30分钟对100分钟±34分钟），与对照组相比无显著差异（77分钟±20分钟对83分钟±23分钟）。克罗恩病患者运动前已被激活的中性粒细胞运动后化学发光增强，与对照组相似。克罗恩病患者运动后尿锌排出量显著增加，而对照组受试者则无变化。
适度有氧运动对所检测的胃肠参数无显著影响。然而，克罗恩病患者的基础中性粒细胞激活及运动可能会引发氧代谢产物的过度产生。此外，运动可能会增加锌缺乏的风险。
