Dechet C B, Bostwick D G, Blute M L, Bryant S C, Zincke H
Department of Urology, Mayo Clinic, Rochester, Minnesota 55905, USA.
J Urol. 1999 Jul;162(1):40-2. doi: 10.1097/00005392-199907000-00010.
We analyzed a large series of cases of renal oncocytoma to define the incidence of coexistent renal cell carcinoma, multifocality, bilateralism and metachronous tumor development.
Between 1980 and 1997, 100 men and 38 women with a mean age of 68 years with oncocytoma, were treated surgically at our institution. We analyzed tumor characteristics and reviewed specimens for coexistent renal cell carcinoma.
Tumors were discovered incidentally in 58% of the cases. Specimens were obtained from 84 radical and 70 partial nephrectomies. Tumor size ranged from 0.3 to 14.5 cm. (median 3.2). Oncocytoma was unilateral in 131 cases (95%) and bilateral in 7 (5%), while there were multiple oncocytomas in 8 (6%). Mean followup was 41 months (range 0 to 200). The disease specific survival rate was 100% and no patient had metastasis. In 6 patients (4%) metachronous oncocytoma developed during followup. No patient had locally recurrent oncocytoma after partial nephrectomy for a solitary renal oncocytoma. Renal cell carcinoma and oncocytoma were found in 14 patients (10%), including unilateral synchronous disease in 9 and bilateral synchronous disease in 5.
Our data support the benign nature of renal oncocytoma. Multifocality, bilateralism and metachronous tumor develop in approximately 4 to 6% of all cases. Renal cell carcinoma coexisted in 10% of oncocytoma cases.
我们分析了大量肾嗜酸细胞瘤病例，以确定肾细胞癌共存、多灶性、双侧性和异时性肿瘤发生的发生率。
1980年至1997年间，我院对100例男性和38例女性肾嗜酸细胞瘤患者进行了手术治疗，患者平均年龄68岁。我们分析了肿瘤特征，并对标本进行检查以确定是否存在共存的肾细胞癌。
58%的病例肿瘤为偶然发现。标本取自84例根治性肾切除术和70例部分肾切除术。肿瘤大小范围为0.3至14.5厘米（中位数3.2厘米）。131例（95%）嗜酸细胞瘤为单侧性，7例（5%）为双侧性，8例（6%）为多发嗜酸细胞瘤。平均随访时间为41个月（范围0至200个月）。疾病特异性生存率为100%，无患者发生转移。6例（4%）患者在随访期间出现异时性嗜酸细胞瘤。对于孤立性肾嗜酸细胞瘤行部分肾切除术后，无患者出现局部复发性嗜酸细胞瘤。14例（10%）患者同时存在肾细胞癌和嗜酸细胞瘤，其中9例为单侧同步性疾病，5例为双侧同步性疾病。
我们的数据支持肾嗜酸细胞瘤的良性性质。多灶性、双侧性和异时性肿瘤发生在所有病例中的比例约为4%至6%。10%的嗜酸细胞瘤病例中存在肾细胞癌共存。
