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幼年皮肌炎和混合性结缔组织病中毛细血管密度降低。

Decreased capillary density in juvenile dermatomyositis and in mixed connective tissue disease.

作者信息

Scheja A, Elborgh R, Wildt M

机构信息

Department of Rheumatology, University Hospital at Lund, Sweden.

出版信息

J Rheumatol. 1999 Jun;26(6):1377-81.

PMID:10381059

Abstract

OBJECTIVE

To assess whether quantitative capillary microscopy is a useful tool to evaluate capillary abnormalities in children with connective tissue diseases.

METHODS

Eight children with juvenile dermatomyositis (JDM), 6 with mixed connective tissue disease (MCTD) and 23 healthy children were investigated with computer based quantitative capillary microscopy. Median disease duration was 1 year among JDM (1-4) and 3 years (1-7) among MCTD.

RESULTS

Capillary density was decreased in JDM [median 2.5 (1.4-4.3) loops/mm (p < 0.001)] and in MCTD [median 5.0 (4.1-7.0) loops/mm (p < 0.05)] compared to healthy controls [median 6.8 (5.3-8.0) loops/mm]. Median capillary loop area was increased in JDM [median 8.5 (3.0-15.8) 10(-3) mm2 (p < 0.001)] and in MCTD [median 4.5 (3.0-6.0) 10(-3) mm2 (p < 0.02)] compared to controls [median 2.5 (1.0-4.0) 10(-3) mm2].

CONCLUSION

Quantitative nailfold capillary microscopy is a sensitive indicator of JDM. In MCTD this technique is less discriminative.

摘要

目的

评估定量毛细血管显微镜检查是否是评估结缔组织病患儿毛细血管异常的有用工具。

方法

对8名幼年皮肌炎（JDM）患儿、6名混合性结缔组织病（MCTD）患儿和23名健康儿童进行基于计算机的定量毛细血管显微镜检查。JDM患儿的疾病中位病程为1年（1 - 4年），MCTD患儿为3年（1 - 7年）。

结果

与健康对照组[中位值6.8（5.3 - 8.0）个袢/mm]相比，JDM组[中位值2.5（1.4 - 4.3）个袢/mm（p < 0.001）]和MCTD组[中位值5.0（4.1 - 7.0）个袢/mm（p < 0.05）]的毛细血管密度降低。与对照组[中位值2.5（1.0 - 4.0）×10⁻³mm²]相比，JDM组[中位值8.5（3.0 - 15.8）×10⁻³mm²（p < 0.001）]和MCTD组[中位值4.5（3.0 - 6.0）×10⁻³mm²（p < 0.02）]的毛细血管袢面积增加。