Arizpe S R, Hornstein O P, Deinlein E
Z Hautkr. 1984 May 1;59(9):593-600.
Capillary microscopic investigations of the nailfold were performed in 38 patients presenting Raynaud's phenomenon (systemic sclerosis: diffuse type n = 6; systemic sclerosis: CREST syndrome n = 21; Raynaud's disease n = 7; mixed connective tissue disease (MCTD) n = 4). A control group of 15 healthy persons was investigated for comparison. 3 stages of capillary alteration were established in patients with systemic sclerosis by recording number (per 2 mm microscopic field diameter), morphology, colour and size of nailfold capillaries. Additional criteria like pericapillary microhemorrhages and disordered capillary blood flow were considered as well. Significant correlations of capillary microscopie findings to different subsets of systemic sclerosis including MCTD could not be proven. Cases provisionally classified as Raynaud's disease could not be assigned to systemic sclerosis on account of capillary microscopy. A clear correlation was found, however, between the grade of capillary alteration and both severity of clinical features and duration of the disease. All cases with capillary changes of stage 3 showed clinical correlation to esophageal dysmotility , also proven in 7 out of 13 patients with stage 2 capillary alteration.
对38例出现雷诺现象的患者进行了甲襞毛细血管显微镜检查（系统性硬化症：弥漫型n = 6；系统性硬化症：CREST综合征n = 21；雷诺病n = 7；混合性结缔组织病（MCTD）n = 4）。为作比较，对15名健康人组成的对照组进行了检查。通过记录甲襞毛细血管的数量（每2毫米显微镜视野直径）、形态、颜色和大小，确定了系统性硬化症患者毛细血管改变的3个阶段。还考虑了诸如毛细血管周围微出血和毛细血管血流紊乱等其他标准。未能证实毛细血管显微镜检查结果与包括MCTD在内的系统性硬化症不同亚型之间存在显著相关性。根据毛细血管显微镜检查，暂时归类为雷诺病的病例无法归为系统性硬化症。然而，发现毛细血管改变的程度与临床特征的严重程度和疾病持续时间之间存在明显相关性。所有3期毛细血管改变的病例均显示与食管动力障碍存在临床关联，在13例2期毛细血管改变的患者中，也有7例得到证实。
