Betteridge D J
Department of Medicine, University College, London, UK.
Eur J Clin Invest. 1999 Jun;29 Suppl 2:12-6. doi: 10.1046/j.1365-2362.1999.00002.x.
Type 2 diabetic patients have an increased risk of cardiovascular disease and, although many factors contribute to this risk, it is likely that diabetic dyslipidaemia plays an important role. Dyslipidaemia in Type 2 diabetic patients is characterized by low levels of HDL cholesterol and high triglyceride levels. In Type 2 diabetes, the total amount of LDL cholesterol is the same as in healthy people, but there are qualitative changes, e.g. a shift to smaller, denser LDL particles and an increased susceptibility to oxidation. Oxidized LDL may promote the development of atherosclerosis. It is possible to modify the major abnormalities of diabetic dyslipidaemia by combining lifestyle modifications (e.g. increased physical activity, cessation of smoking and weight reduction) with improved glycaemic control and hypolipidaemic drugs to reduce the burden of CVD within this high-risk population.
2型糖尿病患者患心血管疾病的风险增加，尽管有许多因素导致这种风险，但糖尿病血脂异常可能起重要作用。2型糖尿病患者的血脂异常表现为高密度脂蛋白胆固醇水平低和甘油三酯水平高。在2型糖尿病中，低密度脂蛋白胆固醇的总量与健康人相同，但存在质的变化，例如向更小、更致密的低密度脂蛋白颗粒转变以及氧化易感性增加。氧化型低密度脂蛋白可能促进动脉粥样硬化的发展。通过将生活方式改变（如增加体育活动、戒烟和减重）与改善血糖控制及降血脂药物相结合，有可能改善糖尿病血脂异常的主要异常情况，以减轻这一高危人群的心血管疾病负担。
