Ritzau M, Therkildsen P
Int J Oral Surg. 1978 Dec;7(6):534-40. doi: 10.1016/s0300-9785(78)80070-2.
In a double-blind study dental cones containing the antifibrinolytically active propylic ester of p-hydroxybenzoic acid (PEPH), sulfanilamide and sulfathiazol or placebo were placed in dental sockets following removal of impacted mandibular third molars on 95 consecutive patients, 50 women and 45 men. The duration of the operation, the type of surgeon, preoperative symptoms and the use of peroral anticonception were recorded. The patients were asked to return to the clinic on the seventh postoperative day, and it was then noted whether the healing was disturbed by Alveolitis Sicca Dolorosa (ASD) or not. Statistical analysis showed a significantly prophylactic effect of PEPH against ASD. The prophylactic effect was most pronounced in the group of male patients without preoperative symptoms and in the group of patients operated by dental students. It could not be demonstrated that the sulfa drugs in the cones were of any benefit to the healing of the socket.
在一项双盲研究中，对95例连续患者（50名女性和45名男性）在拔除下颌阻生第三磨牙后，将含有抗纤维蛋白溶解活性的对羟基苯甲酸丙酯（PEPH）、磺胺和磺胺噻唑或安慰剂的牙用锥形物置于牙槽窝内。记录手术持续时间、外科医生类型、术前症状以及口服避孕药的使用情况。要求患者在术后第七天返回诊所，然后记录愈合是否受到干性疼痛性牙槽炎（ASD）的干扰。统计分析表明，PEPH对ASD有显著的预防作用。这种预防作用在术前无症状的男性患者组和由牙科学生进行手术的患者组中最为明显。无法证明锥形物中的磺胺类药物对牙槽窝愈合有任何益处。
