MacGregor A J, Hutchinson D
Int J Oral Surg. 1975 Oct;4(5):184-90. doi: 10.1016/s0300-9785(75)80024-x.
A double-blind, placebo-controlled trial was carried out to study the value of cones containing sulfanilamide and sulfathiazole in the healing of third molar sockets. On the seventh postoperative day, 94 patients were examined regarding pain, swelling and the overall effect of the operation. Trials were run to compare sulfa cones directly with a placebo: in addition, the placebo and sulfa drugs were each compared with the effects of no medication. Pairs were made of the left and right mandibular third molars in the same patient and the results assessed by sequential analysis. It was found that although sulfa cones were better than the placebo, they themselves were no better or worse than leaving the socket alone.
进行了一项双盲、安慰剂对照试验，以研究含磺胺和磺胺噻唑的牙胶在第三磨牙拔牙窝愈合中的作用。术后第七天，对94例患者的疼痛、肿胀及手术总体效果进行了检查。试验将磺胺牙胶直接与安慰剂进行比较：此外，还将安慰剂和磺胺类药物分别与不使用药物的效果进行了比较。将同一患者的左右下颌第三磨牙配对，并通过序贯分析评估结果。结果发现，虽然磺胺牙胶比安慰剂效果好，但与不处理拔牙窝相比，其效果并无差异。
