Yamamoto T, Keighley M R
University Department of Surgery, Queen Elizabeth Hospital, Edgbaston, Birmingham, UK.
Surg Today. 1999;29(6):579-80. doi: 10.1007/BF02482360.
The purpose of this retrospective study was to examine the influence of cigarette smoking on the recurrence of Crohn's disease after resection. Between 1975 and 1990, 141 patients underwent primary ileocolonic resection for ileocecal Crohn's disease, 79 of whom were nonsmokers and 62 of whom were smokers at the time of their operation. The 5- and 10-year cumulative recurrence-free rates were 65% and 45% for the smokers, and 81% and 64% for the nonsmokers, the former values being significantly lower than the latter values (P = 0.007). The smokers were further divided into two subgroups according to the number of cigarettes smoked per day; as mild smokers who smoked fewer than 15 per day (n = 31) and heavy smokers who smoked 15 or more per day (n = 31). The cumulative recurrence-free rate was lower in the heavy smokers compared with the mild smokers. These findings strongly suggest that smoking is associated with a high recurrence rate after ileocolonic resection for ileocecal Crohn's disease.
这项回顾性研究的目的是探讨吸烟对克罗恩病切除术后复发的影响。1975年至1990年间，141例患者因回盲部克罗恩病接受了初次回结肠切除术，其中79例患者在手术时不吸烟，62例患者在手术时吸烟。吸烟者的5年和10年累积无复发率分别为65%和45%，不吸烟者分别为81%和64%，前者显著低于后者（P = 0.007）。根据每天吸烟的数量，吸烟者进一步分为两个亚组；每天吸烟少于15支的轻度吸烟者（n = 31）和每天吸烟15支或更多的重度吸烟者（n = 31）。与轻度吸烟者相比，重度吸烟者的累积无复发率较低。这些发现有力地表明，吸烟与回盲部克罗恩病回结肠切除术后的高复发率有关。
