接受内镜逆行胰胆管造影术（ERCP）的患者与接受冠状动脉造影术的患者的碘吸收情况比较。

Iodine absorption in patients undergoing ERCP compared with coronary angiography.

作者信息

Mönig H, Arendt T, Eggers S, Kloehn S, Fölsch U R

机构信息

Medical Clinic I, University of Kiel, Germany.

出版信息

Gastrointest Endosc. 1999 Jul;50(1):79-81. doi: 10.1016/s0016-5107(99)70349-4.

DOI:10.1016/s0016-5107(99)70349-4

PMID:10385727

Abstract

BACKGROUND

Systemic absorption of iodinated contrast material occurs during endoscopic retrograde cholangiopancreatography (ERCP), the clinical significance of which has not yet been determined.

METHODS

Urinary iodine excretion was measured before and after coronary angiography (n = 20) and ERCP (n = 12). Thyroid hormone levels were determined before iodine load and after 6 and 24 weeks.

RESULTS

Before coronary angiography, iodine excretion was 101 +/- 38.3 micromol/mol creatinine and increased to 865. 10(5) +/- 721. 10(5) micromol/mol on the next day (p </= 0.001). After 6 weeks, it was still elevated (167 +/- 88.8 micromol/mol, p < 0.01). Before ERCP, iodine excretion was 115 +/- 60.3 micromol/mol and reached a peak of 5.3. 10(5) +/- 4.9. 10(5) micromol/mol (p < 0.001). Six weeks later, it had returned to baseline. Two patients in the coronary angiography group but none in the ERCP group had suppressed thyrotropin after 6 weeks.

CONCLUSIONS

The systemic iodine load during ERCP is approximately 0.6% of the iodine load during coronary angiography. Therefore routine measurement of thyroid hormones before ERCP is not recommended.

摘要

背景

在经内镜逆行胰胆管造影术（ERCP）期间会发生碘化造影剂的全身吸收，但其临床意义尚未确定。

方法

测量了冠状动脉造影（n = 20）和ERCP（n = 12）前后的尿碘排泄量。在碘负荷前以及6周和24周后测定甲状腺激素水平。

结果

冠状动脉造影前，碘排泄量为101±38.3微摩尔/摩尔肌酐，次日增加至865×10⁵±721×10⁵微摩尔/摩尔（p≤0.001）。6周后，其仍处于升高状态（167±88.8微摩尔/摩尔，p<0.01）。ERCP前，碘排泄量为115±60.3微摩尔/摩尔，峰值达到5.3×10⁵±4.9×10⁵微摩尔/摩尔（p<0.001）。6周后，其已恢复至基线水平。冠状动脉造影组有2例患者在6周后促甲状腺激素受到抑制，而ERCP组无此情况。