Battaglia M, Ferini Strambi L, Bertella S, Bajo S, Bellodi L
Department of Psychology, University Vita-Salute San Raffaele, Milan, Italy.
Biol Psychiatry. 1999 Apr 15;45(8):1056-8. doi: 10.1016/s0006-3223(98)00213-3.
There is much interest in the identification of polysomnographic markers of liability to the mood disorders that may predate the onset of illness in high-risk subjects, and/or remain altered after remission. One such putative marker is rapid eye movement (REM) density during the first REM period.
Never-depressed subjects with borderline personality disorder (BPD) as a group at high risk for the mood disorders were compared by continuous 48-hour ambulatory electroencephalographic monitoring to age- and gender-matched controls.
Subjects with BPD had significantly higher REM density during the first REM period. One man with BPD who later committed suicide had REM density values exceeding the mean value of his group by 2 SD.
These data extend the view that REM density in the first REM period can be a marker of liability to the mood disorders, as it is present in a group of young subjects at heightened risk for depression.
对于识别可能在高危人群疾病发作之前就存在的、和/或在缓解后仍持续改变的情绪障碍易感性的多导睡眠图标记物，人们有着浓厚的兴趣。一个这样的假定标记物是首个快速眼动（REM）期的快速眼动密度。
通过持续48小时的动态脑电图监测，将从未患过抑郁症的边缘性人格障碍（BPD）患者作为一组情绪障碍高危人群，与年龄和性别匹配的对照组进行比较。
BPD患者在首个REM期的快速眼动密度显著更高。一名后来自杀的BPD男性患者，其快速眼动密度值超过其所在组平均值2个标准差。
这些数据进一步证明，首个REM期的快速眼动密度可作为情绪障碍易感性的一个标记物，因为它在一组抑郁症高危年轻人群中存在。
