Maiello A, Dassio G, Calvo M M, Gramoni A
Dipartimento di Scienze Medico-Chirurgiche, Università degli Studi, Torino.
Minerva Med. 1999 Jan-Feb;90(1-2):33-7.
To assess efficacy and tolerability of pefloxacin in association with other antibiotics in the treatment of acute and chronic bone and joint infections.
From January to December 1997, all the outpatients with diagnosis of acute or chronic bone and joint infections have been enrolled in a perspective study. If possible a cultural or histopathological study was performed. Treatment response was evaluated with radiological and clinical chemistry parameters.
Fifteen patients [10 males, 5 females; mean age 40.7 +/- 15 years (range 15-71)] have been studied. They had 5 knee septic arthritis, 1 sacroileitis, 1 hip septic arthritis, 4 long bone osteomyelitis, 1 sterum osteomyelitis, 3 spondilitis. Three patients were HIV infected. Twelve were acute infections, 3 chronic ones. Overall, 7 were hematogenous infections, 6 subsequent to elective surgery, 1 post-traumatic thighbone osteomyelitis, 1 osteomyelitis by external fixation device. Isolates were S. aureus in 5 cases, P. mirabilis in 1 case, S. aureus+ Serratia marcescens in 1. In the remaining part cultural tests were negative. Pefloxacin was administered i.v. or orally at the dose of 400 mg/bid for a mean time of 114 +/- 74.5 days (range 30-270) in association with other chemotherapic agents. Ten good recoveries, 3 partial and 2 no responses were observed.
Pefloxacin resulted to be useful in the treatment of acute and chronic bone and joint infections. No severe side effect was observed during the treatment.
评估培氟沙星与其他抗生素联合应用于治疗急慢性骨与关节感染的疗效和耐受性。
1997年1月至12月，所有诊断为急慢性骨与关节感染的门诊患者纳入一项前瞻性研究。尽可能进行培养或组织病理学研究。用放射学和临床化学参数评估治疗反应。
研究了15例患者[男10例，女5例；平均年龄40.7±15岁（范围15 - 71岁）]。他们有5例膝关节化脓性关节炎、1例骶髂关节炎、1例髋关节化脓性关节炎、4例长骨骨髓炎、1例胸骨骨髓炎、3例脊柱炎。3例患者感染了HIV。12例为急性感染，3例为慢性感染。总体而言，7例为血源性感染，6例继发于择期手术，1例为创伤后股骨髓炎，1例为外固定装置引起的骨髓炎。分离出的菌株5例为金黄色葡萄球菌，1例为奇异变形杆菌，1例为金黄色葡萄球菌 + 黏质沙雷菌。其余部分培养试验为阴性。培氟沙星与其他化疗药物联合，静脉或口服给药，剂量为400 mg/每日两次，平均用药时间为114±74.5天（范围30 - 270天）。观察到10例完全康复，3例部分康复，2例无反应。
培氟沙星在治疗急慢性骨与关节感染中有效。治疗期间未观察到严重副作用。
