Lee J M, Zipfel G J, Choi D W
Center for the Study of Nervous System Injury and Department of Neurology, Washington University School of Medicine, Saint Louis, Missouri 63110, USA.
Nature. 1999 Jun 24;399(6738 Suppl):A7-14. doi: 10.1038/399a007.
Thrombolysis has become established as an acute treatment for human stroke. But despite multiple clinical trials, neuroprotective strategies have yet to be proved effective in humans. Here we discuss intrinsic tissue mechanisms of ischaemic brain injury, and present a perspective that broadening of therapeutic targeting beyond excitotoxicity and neuronal calcium overload will be desirable for developing the most effective neuroprotective therapies.
溶栓已成为治疗人类中风的一种急性疗法。但尽管进行了多项临床试验，神经保护策略在人类中尚未被证明有效。在此，我们讨论缺血性脑损伤的内在组织机制，并提出一种观点，即对于开发最有效的神经保护疗法而言，将治疗靶点拓宽至兴奋性毒性和神经元钙超载之外是可取的。
