Yee J, Hung R K, Akerkar G A, Wall S D
Department of Radiology (114), Veterans Affairs Medical Center, University of California, San Francisco 94121, USA.
AJR Am J Roentgenol. 1999 Jul;173(1):169-72. doi: 10.2214/ajr.173.1.10397121.
The purpose of this study was to compare colonic distention with and without glucagon hydrochloride during CT colonography.
CT colonography using single breath-hold, thin-section helical technique was performed on 60 patients who were in the supine and prone positions. Magnesium citrate and polyethylene glycol were used for bowel preparation. Colonic air insufflation averaged 30 bulb compressions. Thirty-three patients received IV glucagon (1 mg), and 27 patients did not. The colon was divided into eight segments, and the adequacy of the distention of each segment was evaluated. Overall colonic distention scores, defined as the number of inadequately distended segments (0-8), were recorded for the supine, prone, and combined positions. In the combined position, inadequate distention was defined as identical segments that were inadequately distended in both positions.
A total of 960 segments were evaluated: 528 segments in the glucagon group and 432 segments in the nonglucagon group. In the glucagon group, 444 segments (84.1%) were adequately distended. In the nonglucagon group, 365 segments (84.5%) were adequately distended. The median and range for overall colonic distention scores in the supine, prone, and combined positions were 1 (0-3), 1 (0-3), and 0 (0), respectively, for the glucagon group and 1 (0-6), 1 (0-6), and 0 (0-1), respectively, for the nonglucagon group. We found no statistically significant difference in overall colonic distention between the glucagon group and the nonglucagon group for the supine (p = .84), prone (p = .15), or combined (p = .28) positions.
Glucagon administration before CT colonography does not improve colonic distention.
本研究旨在比较CT结肠成像时使用和不使用盐酸胰高血糖素情况下的结肠扩张情况。
对60例患者采用单次屏气、薄层螺旋技术进行CT结肠成像，患者取仰卧位和俯卧位。使用枸橼酸镁和聚乙二醇进行肠道准备。结肠充气平均进行30次球囊按压。33例患者静脉注射胰高血糖素（1毫克），27例患者未注射。将结肠分为8个节段，评估每个节段的扩张程度。记录仰卧位、俯卧位和联合位的总体结肠扩张评分，该评分定义为扩张不充分节段的数量（0 - 8）。在联合位，扩张不充分定义为在两个体位均扩张不充分的相同节段。
共评估960个节段：胰高血糖素组528个节段，非胰高血糖素组432个节段。在胰高血糖素组，444个节段（84.1%）扩张充分。在非胰高血糖素组，365个节段（84.5%）扩张充分。胰高血糖素组仰卧位、俯卧位和联合位的总体结肠扩张评分中位数及范围分别为1（0 - 3）、1（0 - 3）和0（0），非胰高血糖素组分别为1（0 - 6）、1（0 - 6）和0（0 - 1）。我们发现胰高血糖素组和非胰高血糖素组在仰卧位（p = 0.84）、俯卧位（p = 0.15）或联合位（p = 0.28）的总体结肠扩张方面无统计学显著差异。
CT结肠成像前给予胰高血糖素并不能改善结肠扩张情况。
