Chen H, Lum A, Seifried A, Wilkens L R, Le Marchand L
Etiology Program, Cancer Research Center of Hawaii, University of Hawaii, Honolulu 96813, USA.
Cancer Res. 1999 Jul 1;59(13):3045-8.
The NAD(P)H:quinone oxidoreductase gene, NQO1, often carries a C-->T transition at bp 609, which has been associated with a reduced enzymatic activity and which may result in altered metabolic activation of tobacco smoke procarcinogens. We tested the association of this polymorphism with lung cancer risk in a population-based case-control study of 327 cases and 440 controls of Caucasian, Japanese, or Native Hawaiian ancestry in Hawaii. We found a notable difference in the frequency of the variant allele among Japanese (38%), Caucasians (20%), and Hawaiians (22%). Overall, the variant allele was less frequent in cases than in controls (P = 0.03). A significant inverse association was found in Japanese, with adjusted odds ratios of 0.8 (95% confidence interval, 0.4-1.5) and 0.3 (0.1-0.7) for the heterozygous and homozygous variant genotypes, respectively, compared with the homozygous wild-type genotype (P for genetic trend, 0.02). The association did not reach statistical significance in Caucasians and Hawaiians but was in the same direction.
烟酰胺腺嘌呤二核苷酸磷酸（NAD(P)H）：醌氧化还原酶基因NQO1常常在第609个碱基对处发生C→T转换，这与酶活性降低有关，并且可能导致烟草烟雾前致癌物的代谢活化改变。在夏威夷进行的一项基于人群的病例对照研究中，我们对327例病例和440例高加索人、日本人或夏威夷原住民血统的对照进行了检测，以探究这种多态性与肺癌风险之间的关联。我们发现，日本人群（38%）、高加索人群（20%）和夏威夷人群（22%）中变异等位基因的频率存在显著差异。总体而言，病例组中变异等位基因的频率低于对照组（P = 0.03）。在日本人中发现了显著的负相关，与纯合野生型基因型相比，杂合变异基因型和纯合变异基因型的调整比值比分别为0.8（95%置信区间，0.4 - 1.5）和0.3（0.1 - 0.7）（遗传趋势P值为0.02）。在高加索人和夏威夷人中，这种关联未达到统计学显著性，但方向相同。
