Horrobin D F, Bennett C N
Laxdale Research, Stirling, UK.
Prostaglandins Leukot Essent Fatty Acids. 1999 Apr;60(4):217-34. doi: 10.1054/plef.1999.0037.
Depression and bipolar disorder are two of the commonest illnesses in the developed world. While some patients can be treated effectively with available drugs, many do not respond, especially in the depression related to bipolar disorder. Depression is associated with diabetes, cardiovascular disease, immunological abnormalities, multiple sclerosis, cancer, osteoporosis and ageing: in each case depressed individuals have a worse outcome than non-depressed individuals. In all of these conditions there is now evidence of impaired phospholipid metabolism and impaired fatty acid-related signal transduction processes. Impaired fatty acid and phospholipid metabolism may be a primary cause of depression in many patients and may explain the interactions with other diseases. Several novel gene candidates for involvement in depression and bipolar disorder are proposed.
抑郁症和双相情感障碍是发达国家最常见的两种疾病。虽然一些患者可以用现有药物得到有效治疗，但许多患者并无反应，尤其是与双相情感障碍相关的抑郁症患者。抑郁症与糖尿病、心血管疾病、免疫异常、多发性硬化症、癌症、骨质疏松症和衰老有关：在每种情况下，抑郁个体的预后都比非抑郁个体更差。目前所有这些情况都有磷脂代谢受损和脂肪酸相关信号转导过程受损的证据。脂肪酸和磷脂代谢受损可能是许多患者抑郁症的主要原因，并且可以解释与其他疾病的相互作用。有人提出了几种可能与抑郁症和双相情感障碍有关的新基因候选物。
