兰卡霉素A抑制DNA合成和G1/S期细胞周期进程。
Landomycin A inhibits DNA synthesis and G1/S cell cycle progression.
作者信息
Crow R T, Rosenbaum B, Smith R, Guo Y, Ramos K S, Sulikowski G A
机构信息
Department of Chemistry, Texas A&M University, College Station 77842, USA.
出版信息
Bioorg Med Chem Lett. 1999 Jun 21;9(12):1663-6. doi: 10.1016/s0960-894x(99)00261-9.
Abstract
Landomycin A was found to inhibit the uptake of [3H]thymidine into DNA in murine smooth muscle cells indicating decreased DNA synthesis. Subsequent studies showed that landomycin A inhibits cell cycle progression.
摘要
发现兰多霉素A可抑制[3H]胸苷掺入小鼠平滑肌细胞的DNA中，这表明DNA合成减少。随后的研究表明，兰多霉素A可抑制细胞周期进程。
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