Synthesis of reduced collagen crosslinks.
作者信息
van den Nieuwendijk A M, Benningshof J C, Wegmann V, Bank R A, te Koppele J M, Brussee J, van der Gen A
机构信息
Leiden Institute of Chemistry, Gorlaeus Laboratories, Leiden University, The Netherlands.
出版信息
Bioorg Med Chem Lett. 1999 Jun 21;9(12):1673-6. doi: 10.1016/s0960-894x(99)00252-8.
Abstract
A new synthetic route to reduced collagen crosslinks (LNL and HLNL) is described in this report. It enables an enantioselective synthesis of LNL. HLNL was obtained as a mixture of two diastereoisomers. This method also provides the possibility to introduce radio-labels during the synthesis.
摘要
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