不同尺寸生物陶瓷材料颗粒中的骨生长比较行为。

Comparative bone growth behavior in granules of bioceramic materials of various sizes.

作者信息

Oonishi H, Hench L L, Wilson J, Sugihara F, Tsuji E, Kushitani S, Iwaki H

机构信息

Department of Orthopaedic Surgery, Artificial Joint Section and Biomaterial Research Laboratory, Osaka-Minami National Hospital, 677-2, Kido-Cho, Kawachinagano-Shi, Osaka 586, Japan.

出版信息

J Biomed Mater Res. 1999 Jan;44(1):31-43. doi: 10.1002/(sici)1097-4636(199901)44:1<31::aid-jbm4>3.0.co;2-9.

DOI:10.1002/(sici)1097-4636(199901)44:1<31::aid-jbm4>3.0.co;2-9

PMID:10397902

Abstract

Various bioceramic materials were implanted into 6-mm-diameter holes made in the femoral condyles of mature Japanese white rabbits using different-sized granules to find an optimal material and granule diameter for use as a bone graft. Bioceramics include a bioinert ceramic (Alumina), surface-bioactive ceramics [hydroxyapatite (HAp) and Bioglass(R)], and resorbable bioactive ceramics [alphatricalcium phosphate (alpha-TCP), beta-TCP, tetracalcium phosphate (TeCP), Te. DCPD, Te. DCPA, and low-crystalline HAp]. Granule sizes were 100-300, 10, and 1-3 microm. Bone growth behavior varied with the kind of bioceramic and the size used. For surface-bioactive ceramics, 45S5 Bioglass(R) led to more rapid bone proliferation than synthetic HAp. In resorbable bioactive ceramics, the order of resorption was: low-crystalline HAp and OCP > TeCP, Te DCPD, Te DCPA > alpha-TCP, beta-TCP. In terms of biocompatibility, alpha-TCP was better than beta-TCP.

摘要

将各种生物陶瓷材料以不同大小的颗粒植入成年日本白兔股骨髁上制成的直径6毫米的孔中，以寻找用作骨移植的最佳材料和颗粒直径。生物陶瓷包括生物惰性陶瓷（氧化铝）、表面生物活性陶瓷[羟基磷灰石（HAp）和生物玻璃（R）]以及可吸收生物活性陶瓷[α-磷酸三钙（α-TCP）、β-TCP、磷酸四钙（TeCP）、Te. DCPD、Te. DCPA和低结晶度HAp]。颗粒大小为100 - 300微米、10微米和1 - 3微米。骨生长行为随生物陶瓷种类和所用颗粒大小而变化。对于表面生物活性陶瓷，45S5生物玻璃（R）比合成HAp导致更快的骨增殖。在可吸收生物活性陶瓷中，吸收顺序为：低结晶度HAp和OCP > TeCP、Te DCPD、Te DCPA > α-TCP、β-TCP。在生物相容性方面，α-TCP优于β-TCP。