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掺杂镁的介孔生物活性玻璃纳米颗粒：药物递送与无细胞生物活性

Mesoporous bioactive glass nanoparticles doped with magnesium: drug delivery and acellular bioactivity.

作者信息

Tabia Zakaria, El Mabrouk Khalil, Bricha Meriame, Nouneh Khalid

机构信息

Euromed Research Center, Euromed Engineering Faculty, Euromed University of Fes, Eco-Campus Meknes Road, Campus UEMF, BP51 30 030 Fes Morocco

Laboratory of Physics of Condensed Matter (LPMC), Department of Physics, Ibn Tofail University Kenitra Morocco.

出版信息

RSC Adv. 2019 Apr 17;9(22):12232-12246. doi: 10.1039/c9ra01133a.

DOI:10.1039/c9ra01133a
PMID:35515868
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9063491/
Abstract

The effects of the magnesium doping of binary glass (Si-Ca) on particle texture, on the biomineralization process in simulated body fluid (SBF) as well as on drug loading and release were examined. For this purpose, magnesium-doped binary bioglass nanoparticles (85SiO-(15 - )CaO-MgO, with = 1, 3, 5 and 10 mol%) were prepared by a base catalysed sol-gel method. N adsorption isotherm analysis showed an enhancement in specific surface area as the Mg molar fraction increased. In addition, the FTIR spectra of the samples after soaking in SBF for various periods of time confirmed the presence of new chemical bonds related to the apatite phase, as was also confirmed by SEM observations. XRD patterns of the samples after soaking revealed that the crystallization to form a more stable apatite-like phase was hindered with increasing magnesium content in the glass composition. Furthermore, it was proved that the kinetics of drug release improved with increasing magnesium content. The porosity and the specific surface area were found to be responsible for this improvement.

摘要

研究了二元玻璃（硅 - 钙）中镁掺杂对颗粒质地、在模拟体液（SBF）中的生物矿化过程以及药物负载和释放的影响。为此，通过碱催化溶胶 - 凝胶法制备了镁掺杂的二元生物玻璃纳米颗粒（85SiO-(15 - )CaO - MgO，其中 = 1、3、5 和 10 mol%）。N吸附等温线分析表明，随着镁摩尔分数的增加，比表面积增大。此外，在不同时间段浸泡在SBF中的样品的FTIR光谱证实了与磷灰石相相关的新化学键的存在，SEM观察也证实了这一点。浸泡后样品的XRD图谱表明，随着玻璃组合物中镁含量的增加，形成更稳定的类磷灰石相的结晶受到阻碍。此外，证明了药物释放动力学随着镁含量的增加而改善。发现孔隙率和比表面积是这种改善的原因。

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