Mahr J A, Gooding L R
Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, Georgia 30322, USA.
Immunol Rev. 1999 Apr;168:121-30. doi: 10.1111/j.1600-065x.1999.tb01287.x.
Adenovirus is a human pathogen that infects mainly respiratory and gastrointestinal epithelia. While the pathology caused by this virus is generally not life threatening in immunocompetent individuals, there is a large literature describing its ability to establish a persistent infection. These persistent infections typically occur in apparently healthy individuals with no outward signs of disease. Such a long term and benign interaction between virus and immune system requires adenoviruses to dampen host antiviral effector mechanisms that would otherwise eliminate the virus and cause immune-mediated pathology to the host. Adenovirus devotes a significant portion of its genome to gene products whose sole function seems to be the modulation of host immune responses. This review focuses on what is currently understood about how these immunomodulatory mechanisms work and how they might play a role in maintaining the virus in a persistent state.
腺病毒是一种人类病原体，主要感染呼吸道和胃肠道上皮细胞。虽然这种病毒引起的病理状况在免疫功能正常的个体中通常不会危及生命，但有大量文献描述了其建立持续性感染的能力。这些持续性感染通常发生在表面健康、没有疾病外在迹象的个体中。病毒与免疫系统之间如此长期且良性的相互作用要求腺病毒抑制宿主抗病毒效应机制，否则这些机制会清除病毒并对宿主造成免疫介导的病理状况。腺病毒将其基因组的很大一部分用于编码基因产物，这些基因产物的唯一功能似乎是调节宿主免疫反应。本综述重点关注目前对于这些免疫调节机制如何发挥作用以及它们在使病毒维持在持续状态中可能起到何种作用的理解。
