人类腺病毒 D 种的进化和眼部发病机制的基因组基础。
Genomic foundations of evolution and ocular pathogenesis in human adenovirus species D.
机构信息
Massachusetts Eye and Ear, Harvard Medical School, Boston, MA, USA.
Department of Microbiology and Immunology, University of Oklahoma Health Sciences Center, OK, USA.
出版信息
FEBS Lett. 2019 Dec;593(24):3583-3608. doi: 10.1002/1873-3468.13693. Epub 2019 Dec 11.
Abstract
Human adenovirus commonly causes infections of respiratory, gastrointestinal, genitourinary, and ocular surface mucosae. Although most adenovirus eye infections are mild and self-limited, specific viruses within human adenovirus species D are associated with epidemic keratoconjunctivitis (EKC), a severe and highly contagious ocular surface infection, which can lead to chronic and/or recurrent, visually disabling keratitis. In this review, we discuss the links between adenovirus ontogeny, genomics, immune responses, and corneal pathogenesis, for those viruses that cause EKC.
摘要
人腺病毒通常会引起呼吸道、胃肠道、泌尿生殖道和眼表面黏膜的感染。虽然大多数腺病毒眼部感染是轻微的自限性的，但人类腺病毒 D 种内的特定病毒与流行性角膜结膜炎（EKC）有关，EKC 是一种严重且高度传染性的眼表面感染，可导致慢性和/或复发性、致盲性角膜炎。在这篇综述中，我们讨论了引起 EKC 的那些腺病毒在个体发生、基因组学、免疫反应和角膜发病机制方面的联系。
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