Massachusetts Eye and Ear, Harvard Medical School, Boston, MA, USA.
Department of Microbiology and Immunology, University of Oklahoma Health Sciences Center, OK, USA.
FEBS Lett. 2019 Dec;593(24):3583-3608. doi: 10.1002/1873-3468.13693. Epub 2019 Dec 11.
Human adenovirus commonly causes infections of respiratory, gastrointestinal, genitourinary, and ocular surface mucosae. Although most adenovirus eye infections are mild and self-limited, specific viruses within human adenovirus species D are associated with epidemic keratoconjunctivitis (EKC), a severe and highly contagious ocular surface infection, which can lead to chronic and/or recurrent, visually disabling keratitis. In this review, we discuss the links between adenovirus ontogeny, genomics, immune responses, and corneal pathogenesis, for those viruses that cause EKC.
人腺病毒通常会引起呼吸道、胃肠道、泌尿生殖道和眼表面黏膜的感染。虽然大多数腺病毒眼部感染是轻微的自限性的，但人类腺病毒 D 种内的特定病毒与流行性角膜结膜炎（EKC）有关，EKC 是一种严重且高度传染性的眼表面感染，可导致慢性和/或复发性、致盲性角膜炎。在这篇综述中，我们讨论了引起 EKC 的那些腺病毒在个体发生、基因组学、免疫反应和角膜发病机制方面的联系。
