Burgert H G, Blusch J H
Max von Pettenkofer-lnstitut, Lehrstuhl Virologie, Genzentrum der Ludwig-Maximilians-Universität, München, Germany.
Virus Genes. 2000;21(1-2):13-25.
Persistent viruses have evolved multiple strategies to escape the host immune system. One important prerequisite for efficient viral reproduction in the face of an ongoing immune response is prevention of premature lysis of infected cells. A number of viruses achieve this goal by interfering with antigen presentation and recognition of infected cells by cytotoxic T cells (CTL). Another viral strategy aims to block apoptosis triggered by host defense mechanisms. Both types of strategies seem to be realized by human adenoviruses (Ads). The early transcription unit E3 of Ads encodes proteins that inhibit antigen presentation by MHC class I molecules as well as apoptosis induced by tumor necrosis factor alpha (TNF-alpha) and Fas ligand (FasL). Here, we will describe the organization of the E3 regions of different Ad subgroups and compare the structure and functions of the known immunomodulatory E3 proteins.
持续性病毒已经进化出多种策略来逃避宿主免疫系统。面对持续的免疫反应，病毒高效繁殖的一个重要前提是防止受感染细胞过早裂解。许多病毒通过干扰抗原呈递以及细胞毒性T细胞（CTL）对受感染细胞的识别来实现这一目标。另一种病毒策略旨在阻断宿主防御机制触发的细胞凋亡。这两种策略似乎都由人腺病毒（Ads）实现。腺病毒的早期转录单元E3编码的蛋白质可抑制MHC I类分子的抗原呈递以及肿瘤坏死因子α（TNF-α）和Fas配体（FasL）诱导的细胞凋亡。在这里，我们将描述不同腺病毒亚组E3区域的组织，并比较已知免疫调节E3蛋白的结构和功能。
