Little J L
Eastman Chemical Company, Kingsport, TN 37662-5150, USA.
J Chromatogr A. 1999 Jun 4;844(1-2):1-22. doi: 10.1016/s0021-9673(99)00267-8.
Trimethylsilyl derivatives are routinely employed in gas chromatography to increase the volatility and stability of organic compounds containing active hydrogens. Normally only the desired derivative is formed when organic compounds are derivatized with common silylation reagents. However, some compounds form additional unexpected derivatives or by-products (artifacts). Artifact formation leads to multiple peaks for the same compound or unexpected components in the gas chromatographic analysis of mixtures. This review includes silylation artifacts identified in our laboratory by mass spectrometry during the last 20 years and references to those found in the literature. Also, means of avoiding artifact formation are discussed in detail.
三甲基硅烷基衍生物通常用于气相色谱分析中，以提高含活性氢有机化合物的挥发性和稳定性。通常，当有机化合物用常见的硅烷化试剂进行衍生化时，只会形成所需的衍生物。然而，一些化合物会形成额外的意外衍生物或副产物（假象）。假象的形成会导致在混合物的气相色谱分析中，同一化合物出现多个峰或出现意外成分。本综述涵盖了过去20年我们实验室通过质谱鉴定出的硅烷化假象，以及文献中发现的相关内容。此外，还详细讨论了避免假象形成的方法。
