Frances C D, Go A S, Dauterman K W, Deosaransingh K, Jung D L, Gettner S, Newman J M, Massie B M, Browner W S
Department of Medicine, University of California, Veterans Affairs Medical Center, San Francisco 94121, USA.
Arch Intern Med. 1999 Jul 12;159(13):1429-36. doi: 10.1001/archinte.159.13.1429.
Studies to determine whether care by cardiologists improves the survival of patients with acute myocardial infarction (MI) have produced conflicting results, and it is not known what accounts for differences in patient outcome by physician specialty.
To evaluate whether cardiologists provide more recommended therapies to elderly patients with acute MI and, if so, to determine whether variations in processes of care account for differences in patient outcome.
Retrospective cohort study using medical chart data and administrative data files.
All nonfederal acute care hospitals in California.
A cohort of 7663 Medicare beneficiaries 65 years and older directly admitted to the hospital with a confirmed acute MI from April 1994 to July 1995 with complete data regarding potential contraindications to recommended therapies.
Percentage of "good" and "ideal" candidates for a given acute MI therapy who actually received that therapy, percentage who received exercise stress testing or coronary angiography, percentage who underwent revascularization, and 1-year mortality, stratified by specialty of the attending physician.
During hospitalization, good candidates for aspirin were more likely to receive aspirin if they were treated by cardiologists (87%) than by medical subspecialists (73%; P<.001), general internists (84%; P = .003), or family practitioners (81%; P<.001). Cardiologists were also more likely to treat good candidates with thrombolytic therapy (51%) than were medical subspecialists (29%; P<.001), general internists (40%; P<.001), or family practitioners (27%; P<.001). Patients of cardiologists were 2- to 4-fold more likely to undergo a revascularization procedure. Despite these differences in utilization, we found similar 30-day mortality rates across physician specialties. However, 1-year mortality rates were greater for patients treated by medical subspecialists (odds ratio [OR], 1.9; 95% confidence interval [CI], 1.6-2.3), general internists (OR, 1.4; 95% CI, 1.3-1.6), and family practitioners (OR, 1.7; 95% CI, 1.4-1.9) than for those treated by cardiologists. Adjusting for differences in patient and hospital characteristics markedly reduced the ORs for those treated by medical subspecialists (OR, 1.2; 95% CI, 0.9-1.4), general internists (OR, 1.1; 95% CI, 1.0-1.3), and family practitioners (OR, 1.3; 95% CI, 1.1-1.6), whereas further adjustment for medication use and revascularization procedures had little effect.
Differences in the use of recommended therapies by physician specialty are generally small and do not explain differences in patient outcome. In comparison, differences among patients treated by physicians of various specialties (case mix) have a large impact on patient outcome and may account for the residual survival advantage of patients treated by cardiologists. With the exception of the in-hospital use of aspirin, recommended MI therapies are markedly underused, regardless of the specialty of the physician.
关于心脏病专家的治疗是否能提高急性心肌梗死(MI)患者生存率的研究结果相互矛盾,且尚不清楚医生专业差异导致患者预后不同的原因。
评估心脏病专家是否为老年急性MI患者提供更多推荐治疗,若如此,确定护理过程的差异是否导致患者预后不同。
利用病历数据和管理数据文件进行回顾性队列研究。
加利福尼亚州所有非联邦急症医院。
1994年4月至1995年7月间直接入院的7663名65岁及以上确诊急性MI的医疗保险受益人队列,有关于推荐治疗潜在禁忌症的完整数据。
给定急性MI治疗的“良好”和“理想”候选者实际接受该治疗的百分比、接受运动负荷试验或冠状动脉造影的百分比、接受血运重建的百分比以及1年死亡率,按主治医生专业分层。
住院期间,阿司匹林的良好候选者若由心脏病专家治疗,接受阿司匹林治疗的可能性(87%)高于医学亚专科医生(73%;P<0.001)、普通内科医生(84%;P = 0.003)或家庭医生(81%;P<0.001)。心脏病专家治疗良好候选者进行溶栓治疗的可能性(51%)也高于医学亚专科医生(29%;P<0.001)、普通内科医生(40%;P<0.001)或家庭医生(27%;P<0.001)。心脏病专家的患者接受血运重建手术的可能性高出2至4倍。尽管在治疗利用率上存在这些差异,但我们发现各医生专业的30天死亡率相似。然而,医学亚专科医生(优势比[OR],1.9;95%置信区间[CI],1.6 - 2.3)、普通内科医生(OR,1.4;95% CI,1.3 - 1.6)和家庭医生(OR,1.7;95% CI,1.4 - 1.9)治疗的患者1年死亡率高于心脏病专家治疗的患者。对患者和医院特征差异进行调整后,医学亚专科医生(OR,1.2;95% CI,0.9 - 1.4)、普通内科医生(OR,1.1;95% CI,1.0 - 1.3)和家庭医生(OR,1.3;95% CI,1.1 - 1.6)治疗患者的OR值显著降低,而进一步对用药和血运重建手术进行调整影响不大。
医生专业在推荐治疗使用上的差异通常较小,无法解释患者预后的差异。相比之下,不同专业医生治疗的患者之间的差异(病例组合)对患者预后有很大影响,可能是心脏病专家治疗患者剩余生存优势的原因。除了住院期间使用阿司匹林外,无论医生专业如何,推荐的MI治疗明显未得到充分利用。