Suvisaari J, Haukka J, Tanskanen A, Hovi T, Lönnqvist J
National Public Health Institute, Department of Mental Health and Alcohol Research, Helsinki, Finland.
Am J Psychiatry. 1999 Jul;156(7):1100-2. doi: 10.1176/ajp.156.7.1100.
The authors' goal was to determine whether there is an association between prenatal exposure to poliovirus infection and later development of schizophrenia.
All Finnish patients born between 1951 and 1969 with discharge diagnoses of schizophrenia (N = 13,559) were identified from the Finnish Hospital Discharge Register. Information on the monthly number of cases of paralytic poliomyelitis was obtained for each province in Finland. The authors analyzed the incidence of births of individuals who later developed schizophrenia by using a Poisson regression model with year and place of birth, age, sex, season of birth, and smoothed incidence of poliomyelitis in different gestational periods as explanatory variables.
An association between the incidence of poliomyelitis and the incidence of births 5 months later of individuals who later developed schizophrenia was observed. Without controlling for seasonality, the effect was significant throughout the second trimester.
Second-trimester exposure to poliovirus infection may increase the risk for the later development of schizophrenia.
作者的目标是确定产前接触脊髓灰质炎病毒感染与后期精神分裂症的发展之间是否存在关联。
从芬兰医院出院登记册中识别出所有在1951年至1969年之间出生且出院诊断为精神分裂症的芬兰患者（N = 13559）。获取了芬兰每个省份每月麻痹性脊髓灰质炎病例数的信息。作者使用泊松回归模型，将出生年份和地点、年龄、性别、出生季节以及不同孕期脊髓灰质炎的平滑发病率作为解释变量，分析了后来患精神分裂症个体的出生发生率。
观察到脊髓灰质炎发病率与5个月后后来患精神分裂症个体的出生发生率之间存在关联。在不控制季节性的情况下，整个孕中期这种影响都是显著的。
孕中期接触脊髓灰质炎病毒感染可能会增加后期患精神分裂症的风险。
